Cerebral Ischemic Events with Sickle Cell Anemia
نویسندگان
چکیده
منابع مشابه
Acute silent cerebral ischemic events in children with sickle cell anemia.
BACKGROUND Irregular, sporadic episodes of ischemic brain injury are known to occur in sickle cell anemia (SCA), resulting in overt stroke and silent cerebral infarction. Ongoing ischemia in other organs is common in SCA but has never been documented in the brain. OBJECTIVE To test the hypothesis that acute silent cerebral ischemic events (ASCIEs) are frequent and potentially transient. DES...
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Background: Hemoglobin S arises is the result of a point mutation (A-T) in the sixth codon on the -globin gene on chromosome 11 causing sickle cell anemia. The presence of fetal hemoglobin in infancy plays a relatively protective role for vaso-occlusive symptoms that are the major contributor for the morbidity and mortality among patients with sickle cell anemia. hydroxyurea, an s-phase-specif...
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Sickle cell anemia (SCA)-associated cerebral vasculopathy and moyamoya is a unique entity reflecting the abnormal interactions between sickled red blood cells (RBCs) and the cerebral arterial endothelium. Endothelial injury, coagulation activation, and the inflammatory response generated by sickled RBCs are implicated in the development of cerebral vasculopathy, but the pathophysiology remains ...
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Vanderbilt-Meharry Sickle Cell Center for Excellence, Vanderbilt University Medical Center, Nashville, TN; Department of Radiology, Pediatric Radiology and Neuroradiology, Vanderbilt University Medical Center, Nashville, TN; Department of Radiology, Divisions of Emergency Radiology and Neuroradiology, Vanderbilt University Medical Center , Nashville, TN ; Rodeghier Consultants, Chicago, Illinoi...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 2013
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-27-2-3